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  The dear lab
The DeARLab - Diabetes & Autoimmunity Research Laboratory

SELECTED PUBLICATIONS

Picture
The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Mallone R, Halliez C, Rui J, Herold K C

​go to Pubmed

PictureCurr Opin Endocrinol Diabetes Obes

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective

Samassa F, Mallone R

go to pubmed

PictureDiabetes 2021
CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes
​

Azoury M E, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaout A, Giraud M, Irla M, Lalanne A I, Carré A, Afonso G, Zhou Z, Brandao B, Colli M L, Sebastiani G, Dotta F, Nakayama M, Eizirik D L, You S, Pinto S, Mamula M J, Verdier Y, Vinh J, Buus S, Mathieu C, Overbergh L, Mallone R

​go to pubmed

PictureFront Immunol 2021

Making insulin and staying out of autoimmune trouble: the beta-cell conumndrum

Carré A ,  Mallone R

go to pubmed

PictureDiabetologia 2021
Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Carré A , Richardson SJ, Etienne Larger, Mallone R

go to pubmed
​​

PictureDiabetes 2020
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice

​
Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R

go to pubmed 

PictureDiabetologia 2020
Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

​Mallone R, Eizirk DL

go to pubmed

PictureDiabetes 2020
T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

James A E, Mallone R, Kent S C, DiLorenzo T P

go to pubmed


PictureDiabetologia 2020
miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes

Ventriglia G, Mancarella F, Sebastiani G, Cook D P, Mallone R, Mathieu C, Gysemans C, Dotta F 

go to pubmed

PictureRev Endocr Metab Disord 2019
Structure and function of the exocrine pancreas in patients with type 1 diabetes

Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E

​go to pubmed

PictureMol Ther Methods Clin Dev. 2018
 In Vitro Expansion of Anti-Viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells

​​
Kuranda K, Caillat-Zucman S, You S, Mallone R

​ go to pubmed

PictureEur J Cancer 2018
Autoimmune pancreatitis after nivolum anti-programmed death receptor-1 

Dehghani L, Mikail N, Kramkimel N, Soyer P, Lebtahi R, Mallone R, Larger E

go to pubmed

PictureDiabetes 2018
Inflammation-Induced Citrulinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes 

Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan, G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone, R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L

go to pubmed

PictureCurr Diab Rep 2018
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms 

Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C

go to pubmed

PicturePLoS One 2018
Decreased alfa-cell mass and early structural alterations of the exocrine pancreas in patients wth type 1 diabetes: An analysis based on the nPOD repository 

Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E

go to pubmed




PictureDiabetologia 2018
Combinatorial detection of autoreactive CD8(+) T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S,
Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake
C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R

go to pubmed

PictureCell Metab 2018
Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

Gonzales-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalane AI, Sebastiani G, Carré A, Pinto S, Culina S, Crocos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R

go to pubmed

PictureScience Immunology 2018
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

​Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Osterbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lisina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R, ImMaDiab Study Group
​
go to pubmed   ​Click here for free full text

PictureNature Communications 2016
Loss of immune tolerance to IL-2 in type 1 diabetes

Pérol L, Lindner JM, Nunez NG, Baeyens A, Valle A, Sedlik C, Loirat D, Boyer O, Créange A, Cohen JL, Rogner UC, Yamanouchi J, Marchant M, Leber XC, Scharenberg M, Gagnerault MC, Mallone R, Battaglia M, Santamaria P, Hartemann A, Traggiai E, Piaggio E

go to pubmed

PhotoDiabetes 2015
Maternal-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes

Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Osterbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R

go to pubmed

PhotoSci Transl Med 2015
Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance

Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon BL, Scott DW, Kaveri SV, Mallone R, Lacroix-Desmazes S

go to pubmed

PhotoJ Autoimmun
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

Rosenzwaig M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D

go to pubmed

PhotoDiabetes 2014
Of Bugs and Men: Antigen-Fortified Lactococcus lactis for Type 1 Diabetes Immunotherapy

Mallone R, Culina S

go to pubmed

Photo
Diabetes Obes Metab 2013
Infectious triggers in type 1 diabetes: is there a case for epitope mimicry?

Afonso G, Mallone R

go to pubmed
Photo
Clin Immunol 2013
Biomarkers for immune intervention trials in type 1 diabetes.

Mallone R, Roep BO

go to pubmed


Photo
Diabetes 2012
HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes

Scotto M, Afonso G, Østerbye T, Larger E, Luce S, Raverdy C, Novelli G, Bruno G, Gonfroy-Leymarie C, Launay O, Lemonnier FA, Buus S, Carel JC, Boitard C, Mallone R

go to pubmed
Immagine
Diabetologia 2012
Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients

Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA,Hutton JC, Davidson HW, Mallone R


go to pubmed
Photo
Eur J Immunol 2012
Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice

Brezar V, Culina S, Gagnerault MC, Mallone R

go to pubmed
Photo
PLoS One 2011
T cells recognizing a peptide contaminant undetectable by mass spectrometry

Brezar V, Culina S, Østerbye T, Guillonneau F, Chiappetta G, Verdier Y, Vinh J, Wong FS, Buus S, Mallone R

go to pubmed
Photo
Diabetes 2011
Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes

Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C

go to pubmed
Photo
Diabetes 2011
To B or not to B: (anti)bodies of evidence on the crime scene of type 1 diabetes?

Mallone R, Brezar V

go to pubmed
Photo
Blood 2011
acDCs enhance human antigen-specific T-cell responses

Martinuzzi E, Afonso G, Gagnerault MC, Naselli G, Mittag D, Combadière B, Boitard C, Chaput N, Zitvogel L, Harrison LC, Mallone R

go to pubmed
Photo
Enoc Rev 2011
Beyond the hormone: insulin as an autoimmune target in type 1 diabetes

Brezar V, Carel JC, Boitard C, Mallone R

go to pubmed
Photo
J Exp Med 2011
Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay

Diana J, Brezar V, Beaudoin L, Dalod M, Mellor A, Tafuri A, von Herrath M, Boitard C, Mallone R, Lehuen A

go to pubmed
Photo
Diabetes 2011
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes

Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, Colman PG, Harrison LC

go to pubmed
Photo
J Immunol Methods 2010
Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms

Afonso G, Scotto M, Renand A, Arvastsson J, Vassilieff D, Cilio CM, Mallone R

go to pubmed
Photo
Diabetologia 2009
Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells

Madec AM, Mallone R, Afonso G, Abou Mrad E, Mesnier A, Eljaafari A, Thivolet C

go to pubmed
Photo
J Immunol 2008
Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice

Enée E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P


go to pubmed
Photo
J Immunol Methods 2008
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection

Martinuzzi E, Scotto M, Enée E, Brezar V, Ribeil JA, van Endert P, Mallone R

go to pubmed
Photo
Diabetes 2008
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment

Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R

go to pubmed
Photo
Dibetes 2007
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P

go to pubmed
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