SELECTED PUBLICATIONS
Cold Spring Harb Perspect Med 2024
Cross Talk between β Cells and Immune Cells: What We Know, What We Think We Know, and What We Should Learn
Samassa F, Holtzmann C, Mallone R
go to Pubmed
Samassa F, Holtzmann C, Mallone R
go to Pubmed
Sci Adv 2024
Coxakievirus infection induces direct pancreatic beta cell killing but poor antiviral CD8+ T cell responses
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowwhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent S, Nakayama M, Richardson S, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S, nPOD-virus Working Group, You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R
go to Pubmed
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowwhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent S, Nakayama M, Richardson S, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S, nPOD-virus Working Group, You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R
go to Pubmed
JCEM 2023
Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study
Ettinger R, Buitinga M, Vandamme C, Afonso G, Gomez R, Arribas-Layton D, Bissenova S, Speake C, Reijonen H, Kinnunen T, Overbergh L, Mallone R, Kwok W, James E
go to Pubmed
Ettinger R, Buitinga M, Vandamme C, Afonso G, Gomez R, Arribas-Layton D, Bissenova S, Speake C, Reijonen H, Kinnunen T, Overbergh L, Mallone R, Kwok W, James E
go to Pubmed
Front Neurol 2023
Validation of the Body Scan, a new device to detect a small fibre neuropathy by assessment of the sudomotor function: agreement with t he Sudoscan
Riveline JP, Mallone R, Tiercelin C, Yaker F, Alexandre-Heymann L, Khelifaoui L, Travert F, Fertichon C, Julla JB, Vidal-Trecan T, Potier L, Gautier JF, Larger E, Lefaucheur JP
go to Pubmed
Riveline JP, Mallone R, Tiercelin C, Yaker F, Alexandre-Heymann L, Khelifaoui L, Travert F, Fertichon C, Julla JB, Vidal-Trecan T, Potier L, Gautier JF, Larger E, Lefaucheur JP
go to Pubmed
eBiomed 2023
Tryptophan metabolism promotes immune evasion in human pancreatic β cells
Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R
go to Pubmed
Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R
go to Pubmed
Cells 2023
Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet
De Burghgrave M, Lourenço C, Berthault C, Aiello V, Villalba A, Fouque A, Diedisheim M, You S, Oshima M, Scharfmann R
go to Pubmed
De Burghgrave M, Lourenço C, Berthault C, Aiello V, Villalba A, Fouque A, Diedisheim M, You S, Oshima M, Scharfmann R
go to Pubmed
eBiomed 2023
Gene expression signature predicts rate of type 1 diabetes progression
Suomi T, I Starsksaia, U Kalim, O Rasool, M Jaakkola, T Grönroos, T Välikangas, C Brorsson, G Mazzoni, S Bruggraber, L Overbergh, D Dunger, M Peakman, P Chmura, S Brunak, A Schulte, C Mathieu, M Knip, R Lachesmaa, L Elo, INNODIA Consortium
go to Pubmed
Suomi T, I Starsksaia, U Kalim, O Rasool, M Jaakkola, T Grönroos, T Välikangas, C Brorsson, G Mazzoni, S Bruggraber, L Overbergh, D Dunger, M Peakman, P Chmura, S Brunak, A Schulte, C Mathieu, M Knip, R Lachesmaa, L Elo, INNODIA Consortium
go to Pubmed
Nat Rev Endocrinol 2023
Why does the immune system destroy pancreatic beta-cells but not alpha-cells in type 1 diabetes?
Eizirik D, Szymkzak F, Mallone R
go to Pubmed
Eizirik D, Szymkzak F, Mallone R
go to Pubmed
Front. Endocrinol 2023
In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived iselts: challanges and opportunites
Halliez C, Ibrahim H, Otonkoski T, Mallone R
go to Pubmed
Halliez C, Ibrahim H, Otonkoski T, Mallone R
go to Pubmed
Diabtes 2023
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes
Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizink D, Kent S, Mallone R, , James E
go to Pubmed
Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizink D, Kent S, Mallone R, , James E
go to Pubmed
Diabetes 2022
The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?
Mallone R, Halliez C, Rui J, Herold K C
go to Pubmed
Mallone R, Halliez C, Rui J, Herold K C
go to Pubmed
JPM 2022
Personalized Immunotherapies for Type 1 Diabetes: Who, What, When and How
Deligne C, You, S, Mallone R
go to Pubmed
Deligne C, You, S, Mallone R
go to Pubmed
Curr Opin Endocrinol Diabetes Obes 2022
Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective
Samassa F, Mallone R
go to pubmed
Front Immunol 2021
Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
Perez-Hernandez J, Chiurchiù V, Perruche S, You S
go to Pubmed
Perez-Hernandez J, Chiurchiù V, Perruche S, You S
go to Pubmed
Diabetes 2021
CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes
Azoury M E, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaout A, Giraud M, Irla M, Lalanne A I, Carré A, Afonso G, Zhou Z, Brandao B, Colli M L, Sebastiani G, Dotta F, Nakayama M, Eizirik D L, You S, Pinto S, Mamula M J, Verdier Y, Vinh J, Buus S, Mathieu C, Overbergh L, Mallone R
go to pubmed
Azoury M E, Samassa F, Buitinga M, Nigi L, Brusco N, Callebaout A, Giraud M, Irla M, Lalanne A I, Carré A, Afonso G, Zhou Z, Brandao B, Colli M L, Sebastiani G, Dotta F, Nakayama M, Eizirik D L, You S, Pinto S, Mamula M J, Verdier Y, Vinh J, Buus S, Mathieu C, Overbergh L, Mallone R
go to pubmed
Front Immunol 2021
Making insulin and staying out of autoimmune trouble: the beta-cell conumndrum
Carré A , Mallone R
go to pubmed
Diabetologia 2021
Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
Carré A , Richardson SJ, Etienne Larger, Mallone R
go to pubmed
Carré A , Richardson SJ, Etienne Larger, Mallone R
go to pubmed
Diabetes 2020
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice
Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R
go to pubmed
Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R
go to pubmed
Diabetologia 2020
Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
Mallone R, Eizirk DL
go to pubmed
Mallone R, Eizirk DL
go to pubmed
Diabetes 2020
T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
James A E, Mallone R, Kent S C, DiLorenzo T P
go to pubmed
James A E, Mallone R, Kent S C, DiLorenzo T P
go to pubmed
Diabetologia 2020
miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes
Ventriglia G, Mancarella F, Sebastiani G, Cook D P, Mallone R, Mathieu C, Gysemans C, Dotta F
go to pubmed
Ventriglia G, Mancarella F, Sebastiani G, Cook D P, Mallone R, Mathieu C, Gysemans C, Dotta F
go to pubmed
Rev Endocr Metab Disord 2019
Structure and function of the exocrine pancreas in patients with type 1 diabetes
Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E
go to pubmed
Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E
go to pubmed
Mol Ther Methods Clin Dev. 2018
In Vitro Expansion of Anti-Viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells
Kuranda K, Caillat-Zucman S, You S, Mallone R
go to pubmed
Kuranda K, Caillat-Zucman S, You S, Mallone R
go to pubmed
Eur J Cancer 2018
Autoimmune pancreatitis after nivolum anti-programmed death receptor-1
Dehghani L, Mikail N, Kramkimel N, Soyer P, Lebtahi R, Mallone R, Larger E
go to pubmed
Dehghani L, Mikail N, Kramkimel N, Soyer P, Lebtahi R, Mallone R, Larger E
go to pubmed
Diabetes 2018
Inflammation-Induced Citrulinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan, G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone, R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L
go to pubmed
Buitinga M, Callebaut A, Marques Câmara Sodré F, Crèvecoeur I, Blahnik-Fagan, G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone, R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L
go to pubmed
Curr Diab Rep 2018
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C
go to pubmed
Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C
go to pubmed
PLoS One 2018
Decreased alfa-cell mass and early structural alterations of the exocrine pancreas in patients wth type 1 diabetes: An analysis based on the nPOD repository
Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E
go to pubmed
Bonnet-Serrano F, Diedisheim M, Mallone R, Larger E
go to pubmed
Diabetologia 2018
Combinatorial detection of autoreactive CD8(+) T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop
James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S,
Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake
C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R
go to pubmed
James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S,
Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake
C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R
go to pubmed
Cell Metab 2018
Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
Gonzales-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalane AI, Sebastiani G, Carré A, Pinto S, Culina S, Crocos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R
go to pubmed
Gonzales-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalane AI, Sebastiani G, Carré A, Pinto S, Culina S, Crocos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R
go to pubmed
Science Immunology 2018
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Osterbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lisina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R, ImMaDiab Study Group
go to pubmed Click here for free full text
Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Osterbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lisina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R, ImMaDiab Study Group
go to pubmed Click here for free full text
Nature Communications 2016
Loss of immune tolerance to IL-2 in type 1 diabetes
Pérol L, Lindner JM, Nunez NG, Baeyens A, Valle A, Sedlik C, Loirat D, Boyer O, Créange A, Cohen JL, Rogner UC, Yamanouchi J, Marchant M, Leber XC, Scharenberg M, Gagnerault MC, Mallone R, Battaglia M, Santamaria P, Hartemann A, Traggiai E, Piaggio E
go to pubmed
Pérol L, Lindner JM, Nunez NG, Baeyens A, Valle A, Sedlik C, Loirat D, Boyer O, Créange A, Cohen JL, Rogner UC, Yamanouchi J, Marchant M, Leber XC, Scharenberg M, Gagnerault MC, Mallone R, Battaglia M, Santamaria P, Hartemann A, Traggiai E, Piaggio E
go to pubmed
Diabetes 2015
Maternal-fetal transfer of preproinsulin through the neonatal Fc receptor prevents autoimmune diabetes
Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Osterbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R
go to pubmed
Culina S, Gupta N, Boisgard R, Afonso G, Gagnerault MC, Dimitrov J, Osterbye T, Justesen S, Luce S, Attias M, Kyewski B, Buus S, Wong FS, Lacroix-Desmazes S, Mallone R
go to pubmed
Sci Transl Med 2015
Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance
Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon BL, Scott DW, Kaveri SV, Mallone R, Lacroix-Desmazes S
go to pubmed
Gupta N, Culina S, Meslier Y, Dimitrov J, Arnoult C, Delignat S, Gangadharan B, Lecerf M, Justesen S, Gouilleux-Gruart V, Salomon BL, Scott DW, Kaveri SV, Mallone R, Lacroix-Desmazes S
go to pubmed
J Autoimmun
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
Rosenzwaig M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D
go to pubmed
Rosenzwaig M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D
go to pubmed
Diabetes 2014
Of Bugs and Men: Antigen-Fortified Lactococcus lactis for Type 1 Diabetes Immunotherapy
Mallone R, Culina S
go to pubmed
Mallone R, Culina S
go to pubmed
Diabetes Obes Metab
2013
|
Infectious triggers in type 1 diabetes: is there a case for epitope mimicry?
Afonso G, Mallone R go to pubmed |
Clin Immunol 2013
|
Diabetes 2012
|
HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes
Scotto M, Afonso G, Østerbye T, Larger E, Luce S, Raverdy C, Novelli G, Bruno G, Gonfroy-Leymarie C, Launay O, Lemonnier FA, Buus S, Carel JC, Boitard C, Mallone R go to pubmed |
Diabetologia 2012
|
Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients
Scotto M, Afonso G, Larger E, Raverdy C, Lemonnier FA, Carel JC, Dubois-Laforgue D, Baz B, Levy D, Gautier JF, Launay O, Bruno G, Boitard C, Sechi LA,Hutton JC, Davidson HW, Mallone R go to pubmed |
Eur J Immunol 2012
|
Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice
Brezar V, Culina S, Gagnerault MC, Mallone R go to pubmed |
PLoS One 2011
|
T cells recognizing a peptide contaminant undetectable by mass spectrometry
Brezar V, Culina S, Østerbye T, Guillonneau F, Chiappetta G, Verdier Y, Vinh J, Wong FS, Buus S, Mallone R go to pubmed |
Diabetes 2011
|
Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes
Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C go to pubmed |
Diabetes 2011
|
To B or not to B: (anti)bodies of evidence on the crime scene of type 1 diabetes?
Mallone R, Brezar V go to pubmed |
Blood 2011
|
acDCs enhance human antigen-specific T-cell responses
Martinuzzi E, Afonso G, Gagnerault MC, Naselli G, Mittag D, Combadière B, Boitard C, Chaput N, Zitvogel L, Harrison LC, Mallone R go to pubmed |
Enoc Rev 2011
|
Beyond the hormone: insulin as an autoimmune target in type 1 diabetes
Brezar V, Carel JC, Boitard C, Mallone R go to pubmed |
J Exp Med 2011
|
Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay
Diana J, Brezar V, Beaudoin L, Dalod M, Mellor A, Tafuri A, von Herrath M, Boitard C, Mallone R, Lehuen A go to pubmed |
Diabetes 2011
|
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes
Fourlanos S, Perry C, Gellert SA, Martinuzzi E, Mallone R, Butler J, Colman PG, Harrison LC go to pubmed |
J Immunol Methods 2010
|
Critical parameters in blood processing for T-cell assays: validation on ELISpot and tetramer platforms
Afonso G, Scotto M, Renand A, Arvastsson J, Vassilieff D, Cilio CM, Mallone R go to pubmed |
Diabetologia 2009
|
Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells
Madec AM, Mallone R, Afonso G, Abou Mrad E, Mesnier A, Eljaafari A, Thivolet C go to pubmed |
J Immunol 2008
|
Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice
Enée E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P go to pubmed |
J Immunol Methods 2008
|
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection
Martinuzzi E, Scotto M, Enée E, Brezar V, Ribeil JA, van Endert P, Mallone R go to pubmed |
Diabetes 2008
|
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment
Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R go to pubmed |
Dibetes 2007
|
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes
Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P go to pubmed |
