LATEST PUBLICATIONSPresumption of guilt of T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?
Carré A , Richardson SJ, Etienne Larger, Mallone R Diabetologia 2021 Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice
Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R, Diabetes 2020 Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?
Mallone R, Eizirk DL Diabetologia 2020 T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal
James EA, Mallone R, Kent SC, DiLorenzo TP Diabetes 2020 Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors Gonzales-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalane AI, Sebastiani G, Carré A, Pinto S, Culina S, Crocos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R Cell Metab 2018 
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Osterbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lisina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R, ImMaDiab Study Group Sci Immunol 2018 |
Bienvenus sur le site du Laboratoire DeARLab
Le Laboratoire de Recherche sur le Diabète et l’Auto-immunité (DeARLab) a été établi en 2007 à l'Institut Cochin. Il est affilié à l’Inserm (Institut National de la Santé et de la Recherche Médicale) , à l’Université Paris Descartes et à l’Assistance Publique/Hôpitaux de Paris. En 2008, il est devenu équipe "Avenir", un label d’excellence attribué par l’Inserm à des jeunes équipes qui lancent une thématique de recherche nouvelle et prometteuse. Notre objectif est de comprendre la pathogenèse immunitaire du diabète de type 1 et d’autres maladies auto-immunes. Grâce à des technologies innovantes, nous visons à développer des protocoles de suivi et intervention immunologique pour la classification diagnostique, le traitement et la prévention des maladies auto-immunes. Bonne visite ! Roberto Mallone, MD PhD Sylvaine You, PhD 
Welcome to the DeARLab Website The Diabetes & Autoimmunity Research Laboratory was established in 2007 at the Cochin Institut. It is affiliated with Inserm (Institut National de la Santé et de la Recherche Médicale), the University Paris Descartes and the Assistance Publique/Hôpitaux de Paris. In 2008, it received the "Avenir" label, a prestigious honor assigned by Inserm to young research groups starting a novel high-impact line of research. Our focus is the understanding of the immune pathogenesis of type 1 diabetes and other autoimmune disorders. Through development of innovative technologies, we aim at obtaining "immune staging" protocols for diagnostic classification, treatment and therapeutic prevention of autoimmune diseases. Hope you will enjoy your visit! Roberto Mallone, MD PhD Sylvaine You, PhD |
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